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"The problem here is Assad and the brutality that he's inflicted on the Syrian people, and it has to stop," Obama said at a White House news conference, the BBC reports.
"We're not going to co-operate with a Russian campaign to destroy anyone who is disgusted and fed up with Assad."
He added: "From their [Russia's] perspective, they're all terrorists. And that's a recipe for disaster."
And Obama warned Russian President Vladimir Putin that Russia - and another Assad ally, Iran - faced dangers ahead.